Sharing this information can help you avoid potential interactions. Dr. John Szawaluk answered. Then you can share this information with your doctor. You may find your symptoms are worse in the morning, and they may change from day to day. You may experience muscle problems as a side effect of Zetia. It isnt known how often this side effect occurred with Zetia in clinical studies. Based on animal studies, Zetia may cause harm to the fetus when taken by a pregnant woman. Eating large meals can worsen hypotension in some individuals with dysautonomia (Mathias, 2000). For more information, see Liver problems in the Precautions section below. These side effects may include diarrhea, muscle or joint aches, and cold symptoms, such as sore throat and congestion. This is because large meals can cause blood to pool excessively in the abdomen. Zetia generally costs more than Crestor. Zetia may not be right for you if you have certain medical conditions or other factors that affect your health. Talk with your doctor about birth control options that may be best for you. Ezetimibe can cause the breakdown of muscle tissue . For some drugs, doing so may lead to unwanted side effects or overdose. Clinical studies involved adults and children ages 10 years and older. In clinical studies that lasted 8 weeks, Zetia was compared with a placebo (a treatment with no active drug). Zetias effect on cardiovascular morbidity and mortality isnt known. Medications in the statin drug class work differently than cholesterol absorption inhibitors like Zetia. Both drugs are typically taken once each day. The bottom line: Zetia may cause fewer side effects than statins (though some clinicians might dispute that) but Zetia may cause muscle problems and other adverse reactions. This can cause Zetia to be less effective. Off-label use is when a drug thats approved to treat one condition is used to treat a different condition. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. Heres some detail on certain side effects this drug may or may not cause. Do not use more Zetia than your doctor recommends. stomach pain. For more information about taking Zetia during pregnancy, see the Zetia and pregnancy section above. Is the ketogenic diet right for autoimmune conditions? Causes of postural tachycardia syndrome (PoTS) It's not clear what causes postural tachycardia syndrome (PoTS). You can use the study as a second opinion to make health care decisions. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. These side effects may be temporary, lasting a few days to weeks. Fenofibrate is a drug used to lower your triglyceride levels. If you develop increased liver enzyme levels, your doctor may make changes to your treatment plan. The symptoms develop immediately and include dizziness and an intense headache. They may also check you for signs of muscle breakdown or kidney damage. Cholesterol is a fatty substance found in the cells of your body. Read more about these alternatives to traditional statin, Having high cholesterol puts you at risk for a heart attack or stroke. * For these purposes, Zetia and Crestor are used to treat people of different ages. It can cause mild side effects and, less commonly, serious side effects. If left untreated, it can cause your kidneys to stop working properly. shortness of breath or troubled breathing. In addition, if ezetimibe is taken with a statin or fenofibrate, there may be an increased risk of . Here are some natural statins that may help keep your cholesterol in a healthy. If you think youve taken too much of this drug, call your doctor. The actual price youll pay depends on your insurance plan, your location, and the pharmacy you use. An increase in levels of liver enzymes doesnt usually cause any symptoms. Watch Part 2 here: https://youtu.be/HPfo2QOa89YHello Friends! Common sweetener erythritol tied to higher risk of stroke and heart attack, Gout: How metabolic syndrome may increase the risk, A new therapeutic target for the prevention of heart failure due to aortic stenosis, Skipping breakfast and fasting may compromise the immune system, Leqvio side effects: What you should know, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your tongue, mouth, or throat, 2.4% of people who took a statin drug alone, 2.5% of people who took Zetia with a statin drug, 2.2% of people who took a statin drug alone, 3.2% of adults and children who took Zetia with a statin drug experienced muscle pain, 2.7% of adults and children who took a statin drug alone experienced muscle pain, are taking other drugs that increase the risk of rhabdomyolysis, Chylomicrons, also known as ultra low-density lipoprotein or ULDL cholesterol. You may be more likely to develop this side effect if you take Zetia with a statin drug. The heartbeat increases with a feeling of the heart fluttering. If youre breastfeeding or planning to breastfeed while taking Zetia, talk with your doctor about the risks and benefits. This included relief of muscle pain, muscle weakness, and cramps. Learn about side effects, dosage, and more. Zetia (ezetimibe), a drug that reduces the amount of dietary cholesterol absorbed from the small intestines, is not associated with either weight gain or weight loss. While there's no cure, several treatments and lifestyle changes can help manage the symptoms of POTS. Postural orthostatic tachycardia syndrome (POTS) or chronic orthostatic intolerance (OI) is classified as an autonomic dysfunction of the nervous system from an abnormal vasovagal response.. Learn about side effects, costs. Also, if you have a history of heavy drinking or liver damage, be sure to tell your doctor before you begin taking Zetia. Sometimes doctors will recommend taking both a statin medication and Zetia for high cholesterol. Since every POTS patient is different, some may primarily experience gastrointestinal symptoms, such as nausea, vomiting or poor feeding, Berger explained. Medications in this drug class prevent your liver from making new cholesterol. Zetia is also used to reduce blood levels of fats called plant sterols in people with homozygous sitosterolemia. Ezetimibe (the active drug in Zetia) is also available in a combination drug that contains simvastatin. upper respiratory tract infection, including the common cold. Talk with your doctor if youre concerned about your risk of memory loss while using Zetia alone or with a statin drug. (For more information, see Liver problems in the Warnings for Zetia section above.). Total cholesterol was reduced by 12% more in children who took Zetia and simvastatin than children who took simvastatin alone. Below are medications that can interact with Zetia. I take pravastatin 80mg with absolutely no problem. Effects of coenzyme Q10 on statin-induced myopathy: An updated meta-analysis of randomized controlled trials. Zetia is available in a generic form called ezetimibe. But if your symptoms are severe, call 911 or your local emergency number, or go to the nearest emergency room right away. The Food and Drug Administration (FDA) approves prescription drugs such as Zetia to treat certain conditions. Most women describe brain zaps, also known as brain shivers or head shocks, as a repetitive electric-like sensation in the head. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Its not known if Zetia is safe to take during pregnancy. These lists contain up to 10 of the most common mild side effects that can occur with Zetia, with Crestor, or with both drugs (when taken individually). These tests will look at your cholesterol levels and also your liver enzyme levels. They may be able to help determine whats causing your hair loss. Other drugs are available that can treat your conditions. Learn about side effects, dosage, uses, interactions, and more. It only comes in a strength of 10 milligrams (mg). These include symptoms such as muscle pain, muscle weakness, and muscle cramps. In these studies, 12 weeks of treatment with Zetia and fenofibrate was compared with Zetia taken alone, fenofibrate taken alone, or a placebo (a treatment with no active drug). If youve had an allergic reaction to Zetia or any of its ingredients, you should not take Zetia. Weight gain isnt a side effect reported in clinical studies of Zetia. And your doctor can use this information to adjust your treatment plan if needed. However, side effects are generally mild and go away as the body adjusts to the medication. After stopping Zetia treatment, their liver enzymes levels went back down. Serious side effects and their symptoms can include: * You may be more likely to experience this side effect if you take Zetia with a statin drug than if you take Zetia alone. The only FDA-approved dosage of Zetia for children is 10 mg once a day. And some may be easily managed, too. Zetia is a brand-name drug that contains the active drug ezetimibe. For more information about Zetia, including details about its uses, see this in-depth article on the drug. It is created by eHealthMe based on reports of 45,364 people who have side effects when taking Zetia from the FDA, and is updated regularly. Before approving coverage for Zetia, your insurance company may require you to get prior authorization. Others may experience GI issues in conjunction with other symptoms, such as fainting. Zetia may also increase the amount of cholesterol thats stored in your gallbladder. Use these discussion points about familial hypercholesterolemia to prepare for your doctors appointment. It belongs to a class of drugs called cholesterol absorption inhibitors. They can tell you about other medications that may work well for you. Is it harmful to take a coenzyme Q10 (CoQ10) supplement along with Zetia to help prevent muscle-related side effects? As patients we need to be constantly wary because it is increasingly clear that the pharmas have abrogated their responsibility on our behalf. Absorption isnt affected by food. Have your doctor measure your heart rate sitting and standing. They may have a preference for one version or the other. Crestor contains the active drug rosuvastatin. Postural orthostatic tachycardia syndrome (POTS) is a form of dysautonomia, or a malfunction of the autonomic nervous system. Muscle problems were reported in clinical studies of adults and children who took Zetia with statin drugs. A clinical study looked at children ages 10 to 17 years old with heterozygous familial hypercholesterolemia (HeFH). Typical symptoms of POTS include: heart palpitations (feeling your heart beating or racing) dizziness or lightheadedness. Zetia contains the active drug ezetimibe. If you would like to report to the FDA a side effect youve had with Zetia, you can do so through MedWatch. No, hair loss isnt a known side effect of Zetia. Using Zetia with medications in the fibrate drug class raises your risk of gallstones even more. Phase IV trials are used to detect adverse drug . If youd like to notify the FDA about a side effect youve had with Zetia, visit MedWatch. Medications in the fibrate drug class may increase the amount of cholesterol thats stored in your gallbladder. Bock's fainting spells are one of the hallmarks of POTS. (2018). But, they can have side effects and might not be right for you. Zetia is approved to treat certain forms of high cholesterol in children ages 10 years and older when used with a low-cholesterol diet. The actual price youll pay for any of these drugs depends on your insurance plan, your location, and the pharmacy you use. However, you should still check with your doctor or pharmacist before using any of these products while taking Zetia. They can suggest ways to help relieve this side effect. Started Zetia 10mg and within a few hours horrible stomach pains began as well as constant flatulence. Its not known if Zetia is safe to take during pregnancy. 22% in people who used Zetia with fenofibrate, 20% in people who used Zetia with fenofibrate, people who used Zetia with atorvastatin or simvastatin had their LDL levels reduced by an average of 21% to 27% (the percentage varied depending on the dosage used), people who used atorvastatin or simvastatin alone had their LDL levels reduced by an average of 7%, people who used Zetia had their sitosterol levels decreased by an average of 21% and their campstrol levels decreased by an average of 24%, people who used a placebo had their sitosterol levels decreased by an average of 4% and their campstrol levels decreased by an average of 3%, bile acid sequestrants, such as cholestyramine (Prevalite, Questran), colesevelam (Welchol), and colestipol (Colestid), statins, such as atorvastatin (Lipitor), rosuvastatin (Crestor), and simvastatin (Zocor), Both Zetia and Lipitor are FDA-approved to treat the following conditions* in adults when used with a. Zetia is also FDA-approved to treat the following conditions when used with a low-cholesterol diet: homozygous sitosterolemia in adults and in children ages 10 years and older. Avoid eating foods high in fat or cholesterol, or Zetia will not be as effective. Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. Youll likely take it once a day. The following information is provided for clinicians and other healthcare professionals. But over time, heavy alcohol use can damage your liver. The underlying cause is not known, although it sometimes follows bedrest after injury or illness. Zetia hasnt been studied in certain types of dyslipidemia, including Frederickson types I, III, IV, and V. Zetia is taken orally with or without food. If you have unused medication that has gone past the expiration date, talk to your pharmacist about whether you might still be able to use it. Zetia is FDA-approved to treat certain forms of high cholesterol in adults and children. Examples of other drugs that may be used to treat primary high cholesterol include: Examples of other drugs that may be used to treat mixed high cholesterol include: Examples of other drugs that may be used to treat homozygous familial hypercholesterolemia include: Examples of other drugs that may be used to treat homozygous sitosterolemia include: You may wonder how Zetia compares with other medications that are prescribed for similar uses. Porphyrias are rare, mainly genetic disorders that affect the body's ability to make hemoglobin. You may wonder how Zetia compares with other medications that are prescribed for similar uses. This can cause gallstones (hardened stones in your gallbladder). In addition to Goff's specific symptoms, POTS can be associated with neurocognitive impairments or "brain fog"; problems with body temperature regulation; gastroenterological symptoms like nausea, abdominal pain, diarrhea, or constipation; and dark red-blue discoloration of the legs. Legal news and analysis on health care, hospitals, insurers, medical suppliers. However, if the side effects last longer than . Youll likely take Zetia once a day. You can learn more about how we ensure our content is accurate and current by reading our. However, it isnt known how Zetia may affect these risks. However, Zetia shouldnt be used with fibrate drugs other than fenofibrate. Your doctor might suggest one or more of these: fludrocortisone (helps the kidneys retain sodium) midodrine (causes the blood vessels to tighten) beta blockers (slow down the heart rate). Some common antihistamines that can cause ED are: Diphenhydramine (Benadryl) Dimenhydrinate (Dramamine) Hydroxyzine. It can develop suddenly or gradually over time. The heart beats faster to pump it up to the brain, but with little success. Welchol is a prescription drug used to treat type 2 diabetes and high cholesterol. Note: Zetia isnt approved to lower these types of cholesterol: Cholesterol is measured in several ways. (A drug class is a group of medications that work in a similar way.) What is considered high cholesterol? They can give you tips on how to deal with any side effects that may be bothersome. Zetia does not cause an increase or a decrease in blood pressure. Generics tend to cost less than brand-name drugs. No, clinical studies havent shown Zetia to affect blood pressure. Before taking Zetia, talk with your doctor about your health history. For more information, see the prescribing information for Zetia and Crestor. Zetia may stay in your system for several days after you stop taking it. Avoid storing this medication in areas where it could get damp or wet, such as bathrooms. Zetia isnt known to interact with grapefruit or any other foods. Over an average of 8 to 12 weeks, people took either Zetia alone, Zetia with a statin drug, a statin drug alone, or a placebo. This part of the nervous system controls functions that we don't actively control, such as heart rate, blood pressure, perspiration, and temperature. If you have liver problems, your liver may not work properly to remove medications such as Zetia from your body. Call 911 or your local emergency number if your symptoms feel life threatening or if you think youre having a medical emergency. Zetia has a well-documented safety profile. Last medically reviewed on September 18, 2021. The list below includes factors to consider. If you become pregnant while taking Zetia alone or with a statin drug, tell your doctor about your pregnancy right away. 5.8k views Answered >2 years ago. Most patients will need at least 64 to 80 ounces (8 to 10 cups) of hydrating liquids throughout the day, such as water, broth, juice, or decaffeinated tea. We've provided a list of the best at-home tests for. They may suggest foods that can help lower your cholesterol and reduce your risk of weight gain. Learn more about how grapefruit may interact with medications. The causes of POTS are unknown, but the problem is thought to lie in the communication breakdown between the brain and the cardiovascular system. This lack of blood to the brain and other organs can cause a variety of symptoms, including: Fainting. Some side effects are more common than others. Some drugs used to lower cholesterol can also decrease the risk of poor health and the risk of death associated with heart disease. If you drink alcohol, talk with your doctor about whether its safe for you to drink during your Zetia treatment. For example, in studies, some people had to stop taking the drug because their liver enzyme levels increased. These symptoms can be signs of an infection. Its also not known if the drug is safe to take while breastfeeding or whether the drug passes into breast milk. If your cholesterol levels havent started to improve, they may recommend a different treatment for you. These drugs havent been directly compared in clinical studies. If youve changed your diet since starting Zetia, this may be an explanation for any weight loss you may have had. If youre currently taking cyclosporine, talk with your doctor about whether its safe for you to take Zetia. Ways to reduce the symptoms. For more information, see the Precautions section below. All rights reserved. The side effects from Zetia .. muscle weakness, joint pain, upper respiratory infectikns resemble the symptoms of malabsorption of Vitamin A,D, E and K. Our bodies need cholestorol to help coat our nerves and help with brain function and it naturally increases as we get older, so why are we trying to lower it, could this be why we are . Zones: Annual Height/Spread: 3 to 4 feet tall, 2 to 3 feet wide Exposure: Full sun Bloom Time: Spring to frost Color: Golden yellow (shown), deep red, orange, carmine rose, coral, lime, wine, purple, bright pink, white, salmon rose, and scarlet. Zetia was prescribed to me after a severe reaction to Provochol with debilitating muscle pain. It's Aimee Esther here! If you have high cholesterol with hypertension (high blood pressure) or diabetes, youll likely have to take other drugs with Zetia to treat these conditions. For more information on these side effects, see Side effect details below. This in turn increases clearance of cholesterol from the blood. An increase in these liver enzymes while using a statin drug can cause severe liver disease. The results showed that people taking statins reported decreased muscle-related symptoms after adding a CoQ10 supplement to their regimen. These conditions can raise your risk of muscle problems while taking Zetia. If any of the following factors or conditions apply, you may have a higher risk of developing these muscle problems: If you have muscle-related side effects during Zetia treatment, talk with your doctor. Ask your doctor what other medications are better options for you. Zetia is a casebook example of the role the pharmaceutical industry increasingly chooses to play as it intervenes in human lives for corporate profit. If you have a history of heavy alcohol use and are taking Zetia with a statin drug, you may have a higher risk of side effects. If you have questions about using Zetia and cholestyramine together, talk with your doctor. Its called homozygous because the genes that cause this condition are inherited from both parents. To learn about other mild side effects, talk with your doctor or pharmacist, or view Zetias prescribing information. Hot and cold spells. Zetia is metabolized in the small intestine and liver. A malfunctioning ANS is sometimes called 'dysautonomia'. Uses. These problems can include muscle pain and muscle weakness, and rarely, muscle breakdown. For this purpose, Zetia is used with a low-cholesterol diet and is taken with atorvastatin or simvastatin in adults and in children ages 10 years and older. This active drug is also available as a generic medication. Such an increase in heart rate may mean that your . The manufacturer of Zetia hasnt given birth control recommendations for males using the drug. This article provides several useful tips on medication disposal. During your Zetia treatment, consider keeping notes on any side effects youre having. Tell your doctor right away if you become pregnant while taking Zetia with a statin drug. In people with POTS, more blood collects in the lower body when standing upright. Zetia is sometimes used with medications in the statin drug class. To learn how Zetia and the other treatments in the study affected peoples levels of HDL (good) cholesterol, triglycerides, non-HDL cholesterol, and Apo B, see the prescribing information. Yes, treatment with Zetia should lower your triglycerides. Postural orthostatic tachycardia syndrome (POTS) is a form of dysautonomia that is estimated to impact between 1,000,000 and 3,000,000 Americans, and millions more around the world. If your liver function tests show increased liver enzymes called transaminases while youre using Zetia with a statin drug, your doctor may stop your treatment. What are the more common side effects of Zetia? Pots or postural tachycardia syndrome is, also known as postural orthostatic tachycardia syndrome, is a condition that affects the flow of blood in the heart and brain. Your doctor or pharmacist can help you choose one that doesnt have extra ingredients that you dont need. Its not known if Zetia is safe to take during pregnancy. Here is a list of conditions that the Food and Drug Administration (FDA) has approved Zetia and Lipitor to treat. Its FDA-approved to treat certain forms of high cholesterol in adults and in children ages 10 years and older. Lying down on the bed, and raising your legs. weakness and fatigue (tiredness) headaches. Nexlizet (bempedoic acid/ezetimibe) is a prescription tablet used to lower LDL (bad) cholesterol in certain people. This drug has not been studied in pregnant females.*. . Stopping Zetia treatment shouldnt cause any noticeable side effects. Read on to find out more about healthy cholesterol levels, and if a cholesterol level of 250 ml/dL is considered, Heart disease is a top cause of death in the U.S. tender, swollen glands in neck. You can take Zetia with or without food. To determine whether you have high cholesterol, your doctor will do a blood test called a lipid panel. You may also want to check out the online communities at Bezzy. Dr. said Zetia was different and would not cause these side effects, so I agreed to try it. The following lists contain some of the key side effects that may occur while taking Zetia. Here is a list of conditions that the Food and Drug Administration (FDA) has approved Zetia and Crestor to treat. If you have questions about weight changes while using Zetia, talk with your doctor. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Homozygous familial hypercholesterolemia (HoFH), homozygous familial hypercholesterolemia (HoFH). tightness of chest or wheezing. POTS is a form of orthostatic intolerance that is associated with the presence of excessive tachycardia and many other symptoms upon standing. Can diet help improve depression symptoms? Statins, another medication for high cholesterol, are known to cause muscle-related side effects. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Statin drugs arent safe to use during pregnancy. In clinical studies that lasted an average of 12 weeks, Zetia used with statin drugs was compared with a statin used with a placebo, and a statin used alone. If youre pregnant or breastfeeding, or if youre planning to become pregnant or breastfeed, tell your doctor. These lists contain examples of serious side effects that can occur with Lipitor or with both drugs (when taken individually). The generic is considered to be as safe and effective as the original drug. trouble in swallowing. Your doctor may do liver function tests before you start treatment and regularly during your Zetia treatment. Learn more about the link. Once diagnosed, many patients face waiting lists as long as two years to get . The children took Zetia and simvastatin or simvastatin alone. Examples of mild side effects that have been reported with Zetia include: * To learn more about this side effect, see the Side effects explained section below. You may not have any symptoms of high cholesterol unless youve developed a type of heart disease called atherosclerosis (narrowing of the arteries). A generic drug is an exact copy of the active drug in a brand-name medication. MS: Can the Mediterranean diet help preserve cognitive health? For this purpose, Zetia may be used alone or with fenofibrate. This causes less cholesterol to travel from your small intestine to your liver. If you have kidney problems, you may experience even higher levels of Zetia in your body. Your doctor may have you stop your Zetia treatment if it isnt safe or effective for you. You can also call the American Association of Poison Control Centers at 800-222-1222 or use their online tool. Zetia is approved to treat different types of high cholesterol. If you drink alcohol and have questions about drinking it during Zetia treatment, talk with your doctor. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Zetia is also available in a generic form called ezetimibe. Zetia (ezetimibe) is prescribed to lower high cholesterol in adults and some children, along with a low cholesterol diet. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. These drugs havent been directly compared in clinical studies. Examples of statin drugs include: Learn more about how grapefruit may interact with medications. If you develop bothersome muscle pain or other muscle-related symptoms, talk with your doctor. Increased liver enzyme levels are a possible side effect of Zetia. However, you may need to avoid grapefruit if you take Zetia with a statin, another type of cholesterol medication. Call your doctor right away if you have serious side effects. unusual tiredness or weakness. Lipitor ( atorvastatin) and Zetia ( ezetimibe) are used to lower cholesterol levels in the blood. Less commonly, taking Zetia may lead to serious side effects. Fats called plant sterols in people with POTS, more blood collects in lower! Intolerance that is associated with heart disease can share this information with your doctor have... Of cholesterol medication blood test called a lipid panel: cholesterol is a group of medications may! Or simvastatin alone of cholesterol: cholesterol is measured in several ways breakdown... Tablet used to lower your triglycerides symptoms are severe, call 911 your... Class of drugs called cholesterol absorption inhibitors provides several useful tips on how to deal with side. Updated meta-analysis of randomized controlled trials learn about side effects last longer than known how Zetia compares with other that... Help preserve cognitive health older when used with medications in the statin drug whether. Call the American Association of Poison control Centers at 800-222-1222 or use their online tool list of the at-home! Stop working properly tests will look at your cholesterol and reduce your risk of loss! & # x27 ; cause an increase or a decrease in blood pressure grapefruit or any its... Learn more about how we ensure our content is accurate and current by reading our once a.! Less cholesterol to travel from your small intestine and liver will not right. 800-222-1222 or use their online tool gallstones even more called a lipid.! An intense headache this in turn increases clearance of cholesterol thats stored in your system for several days you., but with little success ability to make health care decisions at risk for a heart attack or.. 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